PhD theses
Please find below the list of PhD theses by the PharMetrX PhD students of the two PharMetrX Chairs at Freie Universität Berlin and the University of Potsdam.
- Viktoria Stachanow
Optimisation of congenital adrenal hyperplasia therapy in paediatric and foetal populations by leveraging pharmacometrics
PhD thesis, Freie Universität Berlin, 2023 - Sabine Stübler
Mathematical model of the mucosal immune response to study inflammatory bowel diseases and their treatments
PhD thesis, Universität Potsdam, 2023 - Ferdinand Anton Weinelt
Towards the rational use of antibiotics: Utilising pharmacometric approaches to improve meropenem and piperacillin treatment in critically ill patients
PhD thesis, Freie Universität Berlin, 2022 - David Busse
Towards precision dosing in morbidly obese patients: Complementary pharmacometric approaches to characterise antibiotic target-site exposure
PhD thesis, Freie Universität Berlin, 2022 - Francis Williams Ojara
Pharmacometric-based characterisation of peripheral neuropathy, tumour growth kinetics and overall survival to identify predictors of toxicity and efficacy to optimise paclitaxel/platinum chemotherapy
PhD thesis, Freie Universität Berlin, 2022 - Anna Mc Laughlin
Towards model-informed precision dosing for targeted anticancer drugs
PhD thesis, Freie Universität Berlin, 2021 - Sebastian Franck
Boosting the innate immune response to enhance antibiotic efficacy: Mechanistic and quantitative insights by amalgamating in vitro, in vivo and in silico
PhD thesis, Freie Universität Berlin, 2021 -
Corinna Maier
Bayesian data assimilation and reinforcement learning for model-informed precision dosing in oncology
PhD thesis, Universität Potsdam, 2021 -
Ana-Marija Grišić
Pharmacometric analysis of monoclonal antibodies to support clinical decision-making
PhD thesis, Freie Universität Berlin, 2021 -
Jane Knöchel
Model reduction of mechanism-based pharmacodynamic models and its link to classical drug effect models
PhD thesis, Universität Potsdam, 2019 -
Lisa Ehmann
Pharmacometric approaches to assess antibiotic dosing in special patient populations: Towards therapeutic decision support
PhD thesis, Freie Universität Berlin, 2019 -
Lena Klopp-Schulze
Towards the individualisation of tamoxifen breast cancer treatment: Leveraging pharmacometric approaches
PhD thesis, Freie Universität Berlin, 2018 -
Eva Göbgen
Impact of human levofloxacin concentrations on Escherichia coli growth/kill/adaptation dynamics in an integrated experimental and semi-mechanistic pharmacokinetic/pharmacodynamic modelling approach
PhD thesis, Freie Universität Berlin, 2018 -
Saskia Fuhrmann
Physiologically-based pharmacokinetic and mechanism-based pharmacodynamic modelling of monoclonal antibodies with a focus on tumour targeting
PhD thesis, Universität Potsdam, 2018 -
Iris Minichmayr
Pharmacometrics-based evaluation of antibiotic target-site exposure to improve dosing regimens in special populations
PhD thesis, Freie Universität Berlin, 2018 -
Christoph Hethey
Cell physiology based pharmacodynamic modeling of antimicrobial drug combinations
PhD thesis, Universität Potsdam, 2017 - Helena Edlund (nee Andersson)
Pharmacokinetic/pharmacodynamic-guided optimisation of monoclonal antibody therapy in special populations
PhD thesis, Freie Universität Berlin, 2017 - Andrea Henrich
Pharmacometric modelling and simulation to optimise paclitaxel combination therapy based on pharmacokinetics, cumulative neutropenia and efficacy
PhD thesis, Freie Universität Berlin, 2017 - Johanna Melin
Pharmacometric approaches to assess hydrocortisone therapy in paediatric patients with adrenal insufficiency
PhD thesis, Freie Universität Berlin, 2017 - Alexander Solms
Integrating nonlinear mixed effects and physiologically–based modeling approaches for the analysis of repeated measurement studies
PhD thesis, Universität Potsdam, 2017 - Sathej Gopalakrishnan
Mathematical modelling of host-disease-drug interactions in HIV disease
PhD thesis, Universität Potsdam, 2016 - Jens Markus Borghardt
Improving the understanding of mechanisms determining the pulmonary and systemic pharmacokinetics of orally inhaled drugs: a pharmacometric analysis
PhD thesis, Freie Universität Berlin, 2016 - Ludivine Fronton
Modeling Approaches to Characterize the Disposition of Monoclonal Antibodies
PhD thesis, Universität Potsdam, 2015 - Sebastian Wicha
Intergrated in vitro and in silico studies for optimisation of broad-spectrum antibiotic combination therapy
PhD thesis, Freie Universität Berlin, 2015 - Andre Schäftlein
Neue Wege in der Modellierung von Mikrodialysedaten im Menschen: Charakterisierung der klinischen ADMER-Prozesse von Moxifloxacin, Levofloxacin und Linezolid in Gesunden und Hochrisikopatienten
PhD thesis, Freie Universität Berlin, 2013 - Ronald Niebecker
Population Pharmacokinetic Modelling and Simulation of Monoclonal Antibodies Including the Impact of Immunogenicity and Importance of Study and Analysis Design Factors
PhD thesis, Freie Universität Berlin, 2013 - Valerie Nock
Pharmacometric Modelling of Processes in the Haematopoietic System and Blood: Leukocyte Progenitor Proliferation and Maturation In Vitro and in Cancer Patients and Erythrocyte Ageing in Diabetic Patients
PhD thesis, Freie Universität Berlin, 2013 - Monika Frank
Population pharmacokinetic modelling and simulation of nevirapine in pregnant women and newborns for dosing strategies to prevent HIV-1 transmission in resource-constrained countries
PhD thesis, Freie Universität Berlin, 2012 - Sabine Pilari
Novel Approaches to Mechanistic Pharmacokinetic/Pharmacodynamic Modeling
PhD thesis, Freie Universität Berlin, 2011