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Students

Iris K. Minichmayr
Pharmacist / Freie Universität Berlin

PhD Student Year Representative
Begin: March 2012 - End: March 2018
Supervisor: Prof. Charlotte Kloft
Co-Supervisor: Prof. Wilhelm Huisinga
Mentor: SANOFI

PhD Project

PhD thesis: Pharmacometrics-based evaluation of antibiotic target-site exposure to improve dosing regimens in special populations.

Scientific interests

Sufficiently high drug concentrations at the target site of action form a key prerequisite for drug effectiveness and treatment success. However, these may substantially differ from corresponding plasma concentrations. Microdialysis has emerged as the method of choice for the determination of unbound, i.e. pharmacologically active, interstitial fluid concentrations of various drugs in peripheral tissues.

My PhD project addresses the analysis of plasma and microdialysis data by means of population pharmacokinetic modelling. Based on clinical data originating from heterogeneous studies involving both healthy volunteers and divergent patient groups, mathematical models shall be built enabling the description and prediction of concentration-time profiles in plasma and at drug target sites. Furthermore, different sources of variability are elucidated and consequently aimed to be assigned to explanatory patient-, disease-, measurement- or study-related factors (covariates). 

Ideally, the developed models will help to assess whether currently employed therapy regimens provide adequate, thus effective and safe concentrations in different compartments of the body and hence aid dosage adjustments in distinct patient populations (e.g. critically ill patients). For instance, antibiotic regimens will be evaluated and new dosing recommendations established in order to prevent both toxicity and therapeutic failure or emergence of bacterial resistance.

Publications

Presentations

  • I.K. Minichmayr, T. Steinke, S. Moritz, S. Beck, F. Kees, M.G. Kees, C. Kloft.
    Determinants of meropenem clearance in ICU patients receiving continuous infusion: value of cystatin C.
    54th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC, USA, 05-09 September 2014.
  • I.K. Minichmayr, A. Schaeftlein, M. Zeitlinger, C. Kloft.
    Pharmacometric analysis of clinical microdialysis data – Adequacy of standard linezolid dosing in different patient groups.
    Tag der Pharmazie of the Deutsche Pharmazeutische Gesellschaft (DPhG), Berlin, Germany, 04 July 2014.
  • I.K. Minichmayr, M. Zeitlinger, C. Kloft.
    Target site pharmacokinetics of doripenem in plasma and interstitial space fluid of peripheral tissues.
    23rd Population Approach Group Europe (PAGE), Alicante, Spain, 10-13 June 2014.
    PAGE 23: 3240, (2014).
  • I.K. Minichmayr, A. Schaeftlein, M. Zeitlinger, C. Kloft.
    Impact of patient- and disease-related characteristics on plasma and target site pharmacokinetics of linezolid in four heterogeneous populations.
    24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Barcelona, Spain, 10-13 May 2014.
    Final Programme, 232, (2014).
  • I.K. Minichmayr, C. Weiser.
    In vitro and in silico approaches to improve clinical drug monitoring and drug development.
    Clinical Microdialysis Symposium Berlin-Buch, Berlin, Germany, 12 December 2014.
  • I.K. Minichmayr, A. Schaeftlein, M. Zeitlinger, C. Kloft.
    A Microdialysate-based Integrated Model with Nonlinear Elimination for Determining Plasma and Tissue Pharmacokinetics of Linezolid in Four Distinct Populations.
    Population Approach Group in Europe, Glasgow, 2013.
  • I.K. Minichmayr, A. Schaeftlein, M. Zeitlinger, C. Kloft.
    Population pharmacokinetics of linezolid in diabetic patients with soft tissue infections – are standard doses adequate?
    23rd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Berlin, 2013.
  • I.K. Minichmayr.
    Modelling clinical microdialysis data - target site pharmacokinetics of linezolid in heterogeneous populations.
    2nd PharMetrX Symposium, Fulda, 2013.
  • I.K. Minichmayr, C. Kloft.
    Pharmacometrics – methodologies, establishment and opportunities of a promising new discipline in Germany.
    Annual Meeting of the Deutsche Pharmazeutische Gesellschaft (DPhG), Greifswald, 2012.
  • I.K. Minichmayr, V. Nock , U. Jaehde, C. Kloft.
    Thrombocytopenia following high-dose chemotherapy with autologous stem cell retransfusion in patients with testicular cell cancer.
    Annual Meeting of the Central European Society of Anticancer Research (CESAR), Essen, 2012.

Education

  • 04/2012-: Graduate Research Training Program ‘Pharmacometrics & Computational Disease Modelling’ at the Freie Universität Berlin
  • 01/2011-02/2011: Pharmacist (St. Martin Gesundheitsapotheke, Apotheke an der Kaiserstraße, Apotheke am Naschmarkt), Vienna
  • 01/2010: Austrian Pharmacy Board Exam, Registration as pharmacist
  • 02/2009-01/2010: Preregistration pharmacist, Apotheke am Naschmarkt, Vienna
  • 03/2007-06/2007: Intern, Hospital pharmacy of Clínica Dávila, Santiago de Chile
  • 02/2007-09/2007: Universidad de Chile, Santiago de Chile: Joint Study Exchange Fellowship
  • 07/2004, 07-08/2005, 07-08/2006: Intern, Department of Quality Assurance, Nycomed Austria GmbH, Linz, Austria
  • 03/2008-10/2008: Research thesis “Expression of Organic Anion Transporting Polypeptides OATP1B3 and OATP3A1 in Ovarian Cancer Cell Lines: Impact on Paclitaxel Resistance and Cell Growth”, Department of Clinical Pharmacy, University of Vienna, Austria
  • 08/2002, 07/2003: Intern, Sonnenapotheke, Linz, Austria
  • 07/2002: Intern, Institute of Nuclear Medicine, Hospital Barmherzige Schwestern, Linz, Austria
  • 07/2001: Intern, Division of Internal Medicine, General Hospital Linz, Austria