Pharmacist / Universität Potsdam
Begin: March 2014 - End: October 2018
Supervisor: Prof. Wilhelm Huisinga
Co-Supervisor: Prof. Charlotte Kloft
Mentor: F. Hoffman - La Roche
Physiologically-based pharmacokinetic and mechanism-based pharmacodynamic modelling of monoclonal antibodies with a focus on tumour targeting (PhD thesis)
Monoclonal antibodies (mAbs) are an innovative group of drugs with increasing clinical importance in oncology, combining high specificity with generally low toxicity. Incomplete drug penetration and heterogeneous distribution within the tumor tissue are currently limitations in cancer therapy. The overall aim of my research is to better understand the mechanisms of monoclonal antibody disposition within tumor tissue in the context of a physiologically-based pharmacokinetic modeling (PBPK) approach.
PBPK models describe the drug concentration in the different tissues based on the physiological structure of the body combining anatomical & physiological knowledge as well as drug-specific information. A PBPK model including a detailed tumor model will be the next step to further investigate the impact of drug therapy on tumor growth. Better understanding of antibody distribution within tumor tissue aids to improve efficacy and safety of cancer therapy and to gain insights for design of new cancer therapies e.g. antibody fragments and new formats like ‘Antibody Drug Conjugates’.In addition to the characteristics of drug and tumor, dynamics of the antigen, targeted by the monoclonal antibody and the immune system may influence disposition of mAbs. Studying the impact of the immune system on mAb PK might be of relevance because human cancer patients are often immunosuppressed as well. All in all it is crucial to understand the pharmacokinetics of mAbs in order to predict pharmacodynamics e.g. receptor occupancy.
- Since 03/2014: Graduate Research Training Program ‘ Pharmacometrics & Computational Disease Modleing’ at University of Potsdam
- 10/2013 - 02/2014: Pharmacist at ‘Apotheke am Kohlhau’, Geising
- 08/2013 - 09/2013: Research Intern at Abbvie Deutschland GmbH, GGCP Pharmacometrics, Ludwigshafen
- 07/2013: Registration as Pharmacist
- 11/2012 - 05/2013: Pharmacist in pre-registration year at Rathaus-Apotheke, Weinböhla
- 05/2012 - 10/2012: Research Intern, University of Florida, Dept. of Pharmaceutics, Gainesville, USA
- 11/2011 - 04/2012: Pharmacist in pre-registration year, Boehringer Ingelheim Pharma GmbH& Co.KG, Respiratory Drug Delivery, Ingelheim
- 2007-2011: Study of Pharmacy, Martin-Luther University Halle-Wittenberg