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A2: Introduction to physiologically-based pharmacokinetics

The module introduces the fundamental concepts of physiologically-based pharmacokinetic (PBPK) modeling. The overall theme of the module is to see PBPK modeling as a way to integrate prior knowledge on physiological processes, anatomical spaces and drug-specific properties into the modeling process and to generate questions (the more questions we ask, the better we are prepared), and test hypotheses.


The module includes mathematical models of principle absorption, distribution, metabolism and excretion (ADME) processes, whole-body PBPK models, lumping of PBPK models and its link to classical compartment models (thereby establishing the link to the A1 PK/PD module), models to predict inter-individual variability and to integrate covariates (thereby establishing the link to the A3 Population analysis module).
 
Note: The modules starts on Friday with an introduction to Matlab, which will be used during the hands-on sessions.

Illustrative schedule

TimeMondayTuesdayWednesdayThursdayFriday
8:45 – 10:45Introduction to PBPK modelingImportant ADME sub-processes, hepatic metabolisms and renal excretionLumping of PBPK models & its relation to classical compartmental modelsInter-individual
variability, extrapolation to children & covariate modeling
Introduction to PBPK modeling of monoclonal antibodies
30 minCoffee break
11:15 - 13:00Introduction to PBPK modeling (con't)Hands-onHands-onHands-onHands-on
60 minLunch break
14:00 - 15:30Tissue model and whole body PBPK models for small molecule drugsA priori prediction of tissue partitioningGuest lecture: Dr. Andreas Reichel, Bayer AG, Project meeting simulationPK-Sim (Bayer AG): Introduction and hands-onPBPK modeling in drug discovery, development and regulatory science
15 minCoffee break
15:45 - 17:00Hands-onHands-on (con't)Project meeting simulation (con't)Hands-on with PK-Sim (con't)
EveningSocial Event (joint event of A1+A2 module)

Contributions:

  • Prof. Wilhelm Huisinga; theoretical lectures
  • PharMetrX PhD students (2nd/3rd year); hands-on exercises
  • External contributions by our faculty members
Venue: Universität Potsdam/Germany
 
Frequency: Every year, typically in March/April.
 

Hard- and software

  • Please bring your own laptop.
  • MATLAB® (The MathWorks), please bring your own Matlab version if possible. Note that there exists a student version (incl. many toolboxes) for appr. 90 USD for PhD students.
  • PK-Sim available for download at Open Systems Pharmacology Suite.

Literature