Software
The PhD students will be familiairzed wtih different software programs and tools during the hands-on exercise of the teaching modules:
- Berkeley Madonna, Macey&Oster (A1 PK/PD)
- MATLAB, The Mathworks (A2 PBPK and A4 Systems Biology)
- Monolix, Lixoft (A3 Population analysis)
- NONMEM, ICON (A3 Population analysis)
- Phoenix WinNonlin, Pharsight (A1 PK/PD)
- Pirana (A3 Population analysis)
- PK-Sim, Bayer Technology Services (A2 PBPK)
- PsN (A3 Population analysis)
- R (A3 Population analysis and A5 Stats&Data analysis)
Some of the software codes used in the teaching modules are publically available:
- Generic PBPK model for small molecule drugs (in Matlab), available as online supplement to Huisinga et al., Modeling inter-individual variability in physiologically-based pharmacokinetics and its link to mechanistic covariate modeling; CPT: Pharmacometrics & Systems Pharmacology, 1 (2012), e4 (Online supplement: parameter values and Matlab files)
Beispieltabelle
| Time | Monday | Tuesday | Wednesday | Thursday | Friday |
|---|---|---|---|---|---|
| 9 am – 10.45 am | Population model development I: Framework, submodels | Model assessment and diagnostics | Simulations with hands-on | Population model development III: PK/PD analysis | |
| 15 min | Coffee break | ||||
| 11 am – 12.45 pm | Population model building | Hands-on: Population PK modelling - Model development II (NONMEM/PsN, Xpose/R) | Advanced model evaluation techniques I with hands-on | Special features in population analysis | |
| 60 min | Lunch break | ||||
| 1.45 pm – 4.45 pm | [Start 1 pm] Welcome and Introduction Recap A1 Population approach I Population approach II | Hands-on: Population PK modelling - Model development I (PsPad, Cluster: NONMEM/PsN) Hands-on: Population PK modelling - Model evaluation (NONMEM/PsN, Xpose/R) | Population model development II: Covariate submodel Hands-on: Covariate PK model building (NONMEM/PsN, Xpose/R) | Advanced model evaluation techniques II: with hands-on (+Pirana) Estimation algorithms (e.g. NONMEM, Monolix) | Summary/Closing Optional seminar: tba |
| 15 min | Coffee break | ||||
| 5 - 6 pm | Wrap-up: Questions & Answers | Wrap-up: Presentation of exercises | Wrap-up: Presentation of exercises | Wrap-up: Questions & Answers | |
| Evening | Social Event (jointly with A4 Systems Biology module, details will be announced in the course) | ||||